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Phospho-CBL (Ser669) monoclonal antibody

货号: MB10674

价格：￥ 1350

货期：现货（1-2个工作日）

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No. :MB10674

Product Name :Phospho-CBL (Ser669) monoclonal antibody

Swiss-Prot :P22681

Host :Rabbit

Reactivity :Human

Applications :WB

Application_all :WB: 1/500-1/1000

Background :This gene is a proto-oncogene that encodes a RING finger E3 ubiquitin ligase. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. This gene has been found to be mutated or translocated in many cancers including acute myeloid leukaemia. Mutations in this gene are also the cause of Noonan syndrome-like disorder

Product :50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Purification&Purity :Affinity Purified

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :IgG

BiowMW :Calculated MW: 100 kDa; Observed MW: 120 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :CBL; CBL2; RNF55; E3 ubiquitin-protein ligase CBL; Casitas B-lineage lymphoma proto-oncogene; Proto-oncogene c-Cbl; RING finger protein 55; Signal transduction protein CBL

Immunogen :A synthetic phosphopeptide corresponding to residues surrounding Ser669 of human CBL

Conjugate :Unconjugated

Modification :Phosphorylated

Western blot analysis of Phospho-CBL in K562 lysates using Phospho-CBL antibody.