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AKT monoclonal antibody

货号: MB10509

价格：￥ 1350

货期：现货（1-2个工作日）

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No. :MB10509

Product Name :AKT monoclonal antibody

Swiss-Prot :Q9Y243

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB,ICC/IF

Application_all :WB: 1/500-1/1000 IF: 1/50-1/200

Background :AKT3 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT3 is the least studied AKT isoform. It plays an important role in brain development and is crucial for the viability of malignant glioma cells. AKT3 isoform may also be the key molecule in up-regulation and down-regulation of MMP13 via IL13. Required for the coordination of mitochondrial biogenesis with growth factor-induced increases in cellular energy demands. Down-regulation by RNA interference reduces the expression of the phosphorylated form of BAD, resulting in the induction of caspase-dependent apoptosis.

Product :50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Purification&Purity :Affinity Purified

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :IgG

BiowMW :Calculated MW: 56 kDa; Observed MW: 56 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :MPPH; PKBG; MPPH2; PRKBG; STK-2; PKB-GAMMA; RAC-gamma; RAC-PK-gamma

Immunogen :A synthetic peptide of human AKT1/2/3

Conjugate :Unconjugated

Modification :Unmodified

Western blot analysis of AKT in 3T3, rat heart lysates using AKT antibody.

免疫沉淀（IP）