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CDK5RAP3 monoclonal antibody

货号: MB10463

价格：￥ 1350

货期：现货（1-2个工作日）

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No. :MB10463

Product Name :CDK5RAP3 monoclonal antibody

Swiss-Prot :Q96JB5

Host :Rabbit

Reactivity :Human,Mouse

Applications :WB,IHC-P,IP

Application_all :WB: 1/500-1/1000 IHC: 1/50-1/100 IP: 1/20

Background :Probable tumor suppressor initially identified as a CDK5R1 interactor controlling cell proliferation (PubMed:12054757, PubMed:12737517). Negatively regulates NF-kappa-B-mediated gene transcription through the control of RELA phosphorylation (PubMed:17785205, PubMed:20228063). Also regulates mitotic G2/M transition checkpoint and mitotic G2 DNA damage checkpoint (PubMed:15790566, PubMed:19223857). Through its interaction with CDKN2A/ARF and MDM2 may induce MDM2-dependent p53/TP53 ubiquitination, stabilization and activation in the nucleus, thereby promoting G1 cell cycle arrest and inhibition of cell proliferation (PubMed:16173922). May play a role in the unfolded protein response, mediating the ufmylation of multiple proteins in response to endoplasmic reticulum stress (PubMed:23152784). May also play a role in the rupture of the nuclear envelope during apoptosis (PubMed:23478299). May regulate MAPK14 activity by regulating its dephosphorylation by PPM1D/WIP1 (PubMed:21283629).

Product :50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Purification&Purity :Affinity Purified

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :IgG

BiowMW :Calculated MW: 57 kDa; Observed MW: 70 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :C53; IC53; LZAP; HSF-27; MST016; PP1553; OK/SW-cl.114

Immunogen :A synthetic peptide of human CDK5RAP3

Conjugate :Unconjugated

Modification :Unmodified

Western blot analysis of CDK5RAP3 in K562, Hela lysates using CDK5RAP3 antibody.

Immunohistochemistry analysis of paraffin-embedded Human breast cancer using CDK5RAP3 antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.