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Phospho-BRAF (Thr401) monoclonal antibody

货号: MB10424

价格：￥ 1350

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :MB10424

Product Name :Phospho-BRAF (Thr401) monoclonal antibody

Swiss-Prot :P15056

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB,IP

Application_all :WB: 1/500-1/1000 IP: 1/20

Background :Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May play a role in the postsynaptic responses of hippocampal neuron. Frequently mutated in thyroid cancers, skin melanomas and at lower frequency in a wide range of human cancers. An activating mutation, mimicking phosphorylation of the activation loop, is seen in 60% of malignant melanoma samples. Raf mutations are generally exclusive to Ras activating mutations.

Product :50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Purification&Purity :Affinity Purified

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :IgG

BiowMW :Calculated MW: 84 kDa; Observed MW: 84 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :BRAF; BRAF1; RAFB1; Serine/threonine-protein kinase B-raf; Proto-oncogene B-Raf; p94; v-Raf murine sarcoma viral oncogene homolog B1

Immunogen :A synthetic phosphopeptide corresponding to residues surrounding Thr401 of human B Raf

Conjugate :Unconjugated

Modification :Phosphorylated

Western blot analysis of Phospho-BRAF in K562, C6, 3T3, Hela lysates using Phospho-BRAF antibody.