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BMI1 monoclonal antibody

货号: MB0119

价格：￥ 1350

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :MB0119

Product Name :BMI1 monoclonal antibody

Swiss-Prot :P35226

Host :Mouse

Reactivity :Human

Applications :WB

Application_all :WB:1:1000

Background :Mel-18 and Bmi-1 are mammalian homologs of Drosophila Pc-g group proteins, as they are similarly expressed during development and implicated in the regulation of gene expression, axial skeleton development, and the control of proliferation and survival of hematopoietic cells. Mel-18 directly binds to DNA through a ring-finger motif and preferentially associates with juxtaposed enhancer elements on various genes, including Bcl-2, c-Myc and Hox. Mel-18 is an immediate early response gene within the c-Myc/Cdc25 signaling cascade that exhibits tumor suppressor activity and negatively regulates cell cycle progression by blocking S phase entry. Alternatively, Bmi-1 has been identified as a potent oncogene as it contributes to the transcriptional activation of genes implicated in early lymphoid development.

Product :1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :BMI1 mAb detects endogenous levels of BMI1 protein.

BiowMW :Predicted band size:43KDa Observed band size:43KDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Cell Cycle Control G1 S Checkpoint,

Alternative Name :Polycomb complex protein BMI-1; Polycomb group RING finger protein 4; RING finger protein 51; BMI1; PCGF4; RNF51

Immunogen :Recombinant full length Human BMI1.

Conjugate :Unconjugated

Modification :Unmodification

Western blot detection of Bmi1 antibody in Hela, A549 and 293T cell lysates using Bmi1 antibody (1:1000 diluted) .

免疫沉淀（IP）

免疫组织化学（IHC）