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ATIC monoclonal antibody

货号: MB0029

价格：￥ 1350

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

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No. :MB0029

Product Name :ATIC monoclonal antibody

Swiss-Prot :P31939

Host :Mouse

Reactivity :Human,Mouse,Rat

Applications :WB

Application_all :WB: 1:1000

Background :The bifunctional purine biosynthesis protein ATIC (also designated PURH) contains AICAR transformylase and IMP cyclohydrolase activities. AICAR (5-aminoimidazole-4-carboxamide ribonucleotide) transformylase catalyzes the second to last step in purine biosynthesis, playing an important role in the production of nucleotides and IMP. Defects in the ATIC transformylase gene can cause AICA-rebsuria, also designated AICA-ribosiduria, an inborn error in purine biosynthesis that is neurologically cataclysmic. Individuals with AICA-rebosuria accumulate AICA-riboside, also designated ZMP, and its derivatives in erythrocytes and fibroblasts. Patients also excrete very large amounts of AICA-riboside in the urine.

Product :1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :This antibody detects endogenous levels of ATIC and does not cross-react with related proteins

BiowMW :Predicted band size:64KDa Observed band size:64KDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase; AICAR transformylase2.IMP cyclohydrolase; ATIC; IMP synthase Inosinicase; PURH; AICAR; AICARFT; IMPCHASE

Immunogen :Recombinant full length Human ATIC.

Conjugate :Unconjugated

Modification :Unmodification

Western blot detection of ATIC in various tissue and cell lysates using ATIC antibody (1:1000 diluted) .