Product Name :RARγ polyclonal antibody（KU）
Application_all :WB: 1:5000~1:10000
Background :Nuclear retinoic acid (RA) receptors (RARs) consist of three subtypes encoded by separate genes: α (NR1B1), β (NR1B2), and γ (NR1B3). For each subtype, there are at least two isoforms, which are generated by differential promoter usage and alternative splicing and differ only in their N-terminal regions. Retinoids, which are metabolites of vitamin A, serve as ligands for RARs. RARs function as ligand-dependent transcriptional regulators and are found to be heterodimerized with retinoid X receptors (RXRs). These transcriptionally active dimers regulate the expression of genes involved in cellular differentiation, proliferation, and apoptosis. Consequently, RARs play critical roles in a variety of biological processes, including development, reproduction, immunity, and organogenesis. RAR mutations, fusion proteins, altered expression levels, or aberrant post-translational modifications result in multiple diseases due to altered RAR function and disruption of homeostasis.
Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.
Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :RARγ polyclonal antibody detects endogenous levels of RARγ protein.
Note :For research use only, not for use in diagnostic procedure.
Pathway :Wntβ catenin signaling,
Alternative Name :Retinoic acid receptor gamma; RAR-gamma; Nuclear receptor subfamily 1 group B member 3; RARG; NR1B3
Immunogen :Synthetic peptide, corresponding to Human RARγ.
Modification :Unmodification
