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TREM2 polyclonal antibody

货号: BZ17066

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BZ17066

Product Name :TREM2 polyclonal antibody

Swiss-Prot :Q9NZC2

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB,IHC-P,ICC/IF

Application_all :WB: 1/500-1/1000 IHC: 1/50-1/100 IF: 1/50-1/200

Background :This gene encodes a membrane protein that forms a receptor signaling complex with the TYRO protein tyrosine kinase binding protein. The encoded protein functions in immune response and may be involved in chronic inflammation by triggering the production of constitutive inflammatory cytokines. Defects in this gene are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL). Alternative splicing results in multiple transcript variants encoding different isoforms.

Product :Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

Purification&Purity :Affinity Purified

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :IgG

BiowMW :Calculated MW: 25 kDa; Observed MW: 25，35-50 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :TREM2; TREM-2; Trem2a; Trem2b; Trem2c; triggering receptor expressed on myeloid cells 2

Immunogen :Recombinant fusion protein containing a sequence corresponding to amino acids 19-160 of human TREM2 (NP_061838.1).HNTTVFQGVAGQSLQVSCPYDSMKHWGRRKAWCRQLGEKGPCQRVVSTHNLWLLSFLRRWNGSTAITDDTLGGTLTITLRNLQPHDAGLYQCQSLHGSEADTLRKVLVEVLADPLDHRDAGDLWFPGESESFEDAHVEHSIS

Conjugate :Unconjugated

Modification :Unmodified

Western blot analysis of TREM2 in various cell lines lysates using TREM2 antibody.

Immunohistochemistry analysis of paraffin-embedded Human tonsil using TREM2 antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.

Immunohistochemistry analysis of paraffin-embedded Human colon carcinoma using TREM2 antibody. High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.

Gut commensal Agathobacter rectalis alleviates microglia-mediated neuroinflammation against pathogenesis of Alzheimer’s disease

Journal10.1016/j.isci.2024.111116

ApplicationWB

IF4.6

SpeciesMouse

PMID39498309