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Phospho-LRRK2 (Ser395) polyclonal antibody

货号: BZ16573

价格：￥ 1350

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BZ16573

Product Name :Phospho-LRRK2 (Ser395) polyclonal antibody

Swiss-Prot :Q5S007

Host :Rabbit

Reactivity :Human,Mouse

Applications :WB,ICC/IF

Application_all :WB: 1/500-1/1000 IF: 1/50-1/200

Background :Positively regulates autophagy through a calcium-dependent activation of the CaMKK/AMPK signaling pathway. The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH, and calcium release from lysosomes. Together with RAB29, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner.

Product :Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Purification&Purity :Affinity Purified

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :IgG

BiowMW :Calculated MW: 286 kDa; Observed MW: 286 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :AURA17; Dardarin antibody; ; Leucine rich repeat kinase 2; LRRK 2 antibody; LRRK2; LRRK2_HUMAN; PARK 8; PARK8; RIPK7; ROCO 2; ROCO2

Immunogen :A synthesized peptide derived from human Phospho-LRRK2 (S935)

Conjugate :Unconjugated

Modification :Phosphorylated

Western blot analysis of Filamin A Phosphorylation in WTLRRK2 lysates treated LRRK2 using Phospho-LRRK2 antibody.