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PMS2 polyclonal antibody

货号: BZ16553

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BZ16553

Product Name :PMS2 polyclonal antibody

Swiss-Prot :P54278

Host :Rabbit

Reactivity :Human

Applications :WB,IHC-P,ICC/IF,IP,FC

Application_all :WB: 1/500-1/1000 IHC: 1/50-1/100 IF: 1/50-1/200 IP: 1/20 FC: 1/50-1/100

Background :Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected.

Product :Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Purification&Purity :Affinity Purified

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :IgG

BiowMW :Calculated MW: 96 kDa; Observed MW: 110 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :DNA mismatch repair gene; DNA mismatch repair protein PMS2; HNPCC4; PMS1 protein homolog 2

Immunogen :A synthesized peptide derived from human PMS2

Conjugate :Unconjugated

Modification :Unmodified

Western blot analysis of PMS2 in Jurkat lysates; HeLa lysates using PMS2 antibody.

Immunohistochemistry analysis of paraffin-embedded Human tonsil using PMS2 antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.