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Cleaved-Caspase 4/5 p20 polyclonal antibody

货号: BZ16485

价格：￥ 1350

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

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No. :BZ16485

Product Name :Cleaved-Caspase 4/5 p20 polyclonal antibody

Swiss-Prot :P49662/P51878

Host :Rabbit

Reactivity :Human

Applications :WB,ELISA

Application_all :WB: 1/500-1/1000 ELISA: 1/10000

Background :CASP4 (caspase 4) encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This caspase is able to cleave and activate its own precursor protein, as well as caspase 1 precursor. When overexpressed, caspase 4 induces cell apoptosis. Alternative splicing results in transcript variants encoding distinct isoforms.

Product :Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

Purification&Purity :Affinity Purified

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :IgG

BiowMW :Calculated MW: 43 kDa; Observed MW: 47,22 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :TX; Mih1; ICH-2; Mih1/TX; ICEREL-II; ICE(rel)II

Immunogen :The antiserum was produced against synthesized peptide derived from human Caspase 4/5. AA range:221-270

Conjugate :Unconjugated

Modification :Cleaved

Western blot analysis of Cleaved-Caspase 4/5 p20 in Jurkat lysates using Caspase 4/5 antibody. The lane on the right is blocked with the Caspase 4/5 peptide.