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HEXIM1 polyclonal antibody

货号: BZ16440

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BZ16440

Product Name :HEXIM1 polyclonal antibody

Swiss-Prot :O94992

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB,IHC-F,IHC-P,ICC/IF,ELISA

Application_all :WB: 1/500-1/1000 IHC: 1/50-1/100 IF: 1/50-1/200 ELISA: 1/10000

Background :Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor (PubMed:14580347, PubMed:15713661, PubMed:15201869). In cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:12832472, PubMed:14580347, PubMed:15713661, PubMed:15201869). May also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity (PubMed:15940264, PubMed:15941832, PubMed:17088550). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728).

Product :Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

Purification&Purity :Affinity Purified

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :IgG

BiowMW :Calculated MW: 41 kDa; Observed MW: 41 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :CLP1; EDG1; HIS1; MAQ1

Immunogen :The antiserum was produced against synthesized peptide derived from human HEXIM1. AA range:181-230

Conjugate :Unconjugated

Modification :Unmodified

Western blot analysis of HEXIM1 in rat HEART lysates using HEXIM1 antibody.

Immunofluorescence analysis of HEXIM1 in HeLa using HEXIM1 antibody. The picture on the right is blocked using the synthesized peptide.