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SNAI1 polyclonal antibody

货号: BZ16397

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BZ16397

Product Name :SNAI1 polyclonal antibody

Swiss-Prot :O95863

Host :Rabbit

Reactivity :Human,Mouse

Applications :WB,IHC-P,ICC/IF,ELISA

Application_all :WB: 1/500-1/1000 IHC: 1/50-1/100 IF: 1/50-1/200 ELISA: 1/10000

Background :Snail is a zinc-finger transcription factor that can repress E-cadherin transcription. Downregulation of E-cadherin is associated with epithelial-mesenchymal transition during embryonic development, a process also exploited by invasive cancer cells . Indeed, loss of E-cadherin expression is correlated with the invasive properties of some tumors and there is a considerable inverse correlation between Snail and E-cadherin mRNA levels in epithelial tumor cell lines . In addition, Snail blocks the cell cycle and confers resistance to cell death . Phosphorylation of Snail by GSK-3 and PAK1 regulates its stability, cellular localization and function .Tissue specificity: Expressed in a variety of tissues with the highest expression in kidney.

Product :Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

Purification&Purity :Affinity Purified

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :IgG

BiowMW :Calculated MW: 29 kDa; Observed MW: 29 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :SNAH; Zinc finger protein SNAI1; Protein snail homolog 1; Protein sna

Immunogen :The antiserum was produced against synthesized peptide derived from human SNAI1. AA range:215-264

Conjugate :Unconjugated

Modification :Unmodified

Western blot analysis of SNAI1 in 3T3 lysates using SNAI1 antibody.

免疫沉淀（IP）