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Phospho-Rb (Ser780) polyclonal antibody

货号: BZ16380

价格：￥ 1350

货期：现货（1-2个工作日）

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No. :BZ16380

Product Name :Phospho-Rb (Ser780) polyclonal antibody

Swiss-Prot :P06400

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB,IHC-F,IHC-P,ICC/IF,ELISA

Application_all :WB: 1/500-1/1000 IHC: 1/50-1/100 IF: 1/50-1/200 ELISA: 1/10000

Background :Cell cycle-dependent phosphorylation by a CDK inhibits Rb target binding and allows cell cycle progression. Rb inactivation and subsequent cell cycle progression likely requires an initial phosphorylation by cyclin D-CDK4/6 followed by cyclin E-CDK2 phosphorylation. Specificity of different CDK/cyclin complexes has been observed in vitro and cyclin D1 is required for Ser780 phosphorylation in vivo.

Product :Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

Purification&Purity :Affinity Purified

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :IgG

BiowMW :Calculated MW: 106 kDa; Observed MW: 106 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :RB1; Retinoblastoma-associated protein; p105-Rb; pRb; Rb; pp110

Immunogen :The antiserum was produced against synthesized peptide derived from human Retinoblastoma around the phosphorylation site of Ser780. AA range:751-800

Conjugate :Unconjugated

Modification :Phosphorylated

Western blot analysis of Phospho-Rb in various lysates using Phospho-Rb antibody.

Western blot analysis of Phospho-Rb in KB lysates using Phospho-Rb antibody.