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Cleaved-Notch1 polyclonal antibody

货号: BZ16348

价格：￥ 1350

货期：现货（1-2个工作日）

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No. :BZ16348

Product Name :Cleaved-Notch1 polyclonal antibody

Swiss-Prot :P46531

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB,ICC/IF,IHC-F,IHC-P,ELISA

Application_all :WB: 1/500-1/1000 IHC: 1/50-1/100 IF: 1/50-1/200 ELISA: 1/10000

Background :Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting.

Product :Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

Purification&Purity :Affinity Purified

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :IgG

BiowMW :Calculated MW: 273 kDa; Observed MW: 110 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :NOTCH1; TAN1; Neurogenic locus notch homolog protein 1; Notch 1; hN1; Translocation-associated notch protein TAN-1

Immunogen :The antiserum was produced against synthesized peptide derived from human Notch 1. AA range:1735-1784

Conjugate :Unconjugated

Modification :Cleaved

Western blot analysis of Cleaved-Notch1 in various lysates using Cleaved-Notch1 antibody.

免疫沉淀（IP）