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LIM Kinase 2 polyclonal antibody

货号: BZ16337

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BZ16337

Product Name :LIM Kinase 2 polyclonal antibody

Swiss-Prot :P53671

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB,IHC-P,ICC/IF

Application_all :WB: 1/500-1/1000 IHC: 1/50-1/100 ICC: 1/100-1/200

Background :Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics (PubMed:10436159, PubMed:11018042). Acts downstream of several Rho family GTPase signal transduction pathways (PubMed:10436159, PubMed:11018042). Involved in astral microtubule organization and mitotic spindle orientation during early stages of mitosis by mediating phosphorylation of TPPP (PubMed:22328514). Displays serine/threonine-specific phosphorylation of myelin basic protein and histone (MBP) in vitro (PubMed:8537403). Suppresses ciliogenesis via multiple pathways; phosphorylation of CFL1, suppression of directional trafficking of ciliary vesicles to the ciliary base, and by facilitating YAP1 nuclear localization where it acts as a transcriptional corepressor of the TEAD4 target genes AURKA and PLK1 (PubMed:25849865).

Product :Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

Purification&Purity :Affinity Purified

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :IgG

BiowMW :Calculated MW: 72 kDa; Observed MW: 72 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :LIM domain kinase 2

Immunogen :Synthetic peptide of human LIMK2

Conjugate :Unconjugated

Modification :Unmodified

Western blot analysis of LIM Kinase 2 in HepG2, HUVEC lysates using LIM Kinase 2 antibody.

Immunohistochemistry analysis of paraffin-embedded Human heart tissue using LIMK2 antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval. Sample with blocking peptide on the right.

Immunofluorescence analysis of LIM Kinase 2 in Hela cells using LIMK2 antibody.