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Phospho-4E BP1 (Thr37) polyclonal antibody

货号: BZ16301

价格：￥ 1350

货期：现货（1-2个工作日）

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No. :BZ16301

Product Name :Phospho-4E BP1 (Thr37) polyclonal antibody

Swiss-Prot :Q13541

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB,IHC-P

Application_all :WB: 1/500-1/1000 IHC: 1/50-1/100

Background :Translation repressor protein 4E-BP1 (also known as PHAS-1) inhibits cap-dependent translation by binding to the translation initiation factor eIF4E. Hyperphosphorylation of 4E-BP1 disrupts this interaction and results in activation of cap-dependent translation. Both the PI3 kinase/Akt pathway and FRAP/mTOR kinase regulate 4E-BP1 activity.

Product :Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

Purification&Purity :Affinity Purified

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :IgG

BiowMW :Calculated MW: 13 kDa; Observed MW: 18 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :EIF4EBP1; Eukaryotic translation initiation factor 4E-binding protein 1; 4E-BP1; eIF4E-binding protein 1; Phosphorylated heat- and acid-stable protein regulated by insulin 1; PHAS-I

Immunogen :Synthetic peptide of human EIF4EBP1

Conjugate :Unconjugated

Modification :Phosphorylated

Western blot analysis of Phospho-4E BP1 in MDAMB435 lysates using Phospho-4E BP1 antibody.

Immunohistochemistry analysis of paraffin-embedded Human breast carcinoma, using 4EBP1 antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval. Sample with blocking peptide on the right.