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Phospho-LAT (Tyr191) polyclonal antibody

货号: BZ16268

价格：￥ 1350

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

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No. :BZ16268

Product Name :Phospho-LAT (Tyr191) polyclonal antibody

Swiss-Prot :O43561

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB,IHC-P,ELISA

Application_all :WB: 1/500-1/1000 IHC: 1/50-1/100 ELISA: 1/10000

Background :Required for TCR (T-cell antigen receptor)- and pre-TCR-mediated signaling, both in mature T-cells and during their development. Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules.

Product :Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

Purification&Purity :Affinity Purified

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :IgG

BiowMW :Calculated MW: 28 kDa; Observed MW: 28 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :LAT; Linker for activation of T-cells family member 1; 36 kDa phospho-tyrosine adapter protein; pp36; p36-38

Immunogen :The antiserum was produced against synthesized peptide derived from human LAT around the phosphorylation site of Tyr191. AA range:191-240

Conjugate :Unconjugated

Modification :Phosphorylated

Immunohistochemistry analysis of paraffin-embedded Human colon cancer using Phospho-LAT antibody.High-pressure and temperature Tris-EDTA pH 8.0 was used for antigen retrieval.Sample with blocking peptide on the right.