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TLR2 polyclonal antibody

货号: BS91352

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS91352

Product Name :TLR2 polyclonal antibody

Swiss-Prot :O60603

Host :Rabbit

Reactivity :Human, Mouse, Rat

Applications :WB ICC/IF

Application_all :WB: 1:500~1:1000 ICC/IF: 1:50~1:200

Background :The TLR family of proteins are characterized by a highly conserved Toll homology (TH) domain, which is essential for Toll-induced signal transduction. TLR1, as well as the other TLR family members, are type I transmembrane receptors that characteristically contain an extracellular domain consisting of several leucine-rich regions along with a single cytoplasmic Toll/IL-1R-like domain. TLR2 and TLR4 are activated in response to lipopolysacchride (LPS) stimulation, which results in the activation and translocation of NFkB and suggests that these receptors are involved in mediating inflammatory responses. Expression of TLR receptors is highest in peripheral blood leukocytes, macrophages, and monocytes. TLR6 is highly homologous to TLR1, sharing greater than 65% sequence identity, and, like other members of TLR family, it induces NFkB signaling upon activation.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity :TLR2 polyclonal antibody detects endogenous levels of TLR2 protein.

BiowMW :~ 105 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Toll-like Receptor signaling,

Alternative Name :TIL4; CD282

Immunogen :Recombinant fusion protein containing a sequence corresponding to amino acids 636-784 of human TLR2 (NP_003255.2).

Conjugate :Unconjugated

Modification :Unmodified

Western blot analysis of extracts of various cell lines, using TLR2 antibody at 1:1000 dilution.

Immunofluorescence analysis of Raw264 7 cells using TLR2 pAb at dilution of 1:200 (40x lens).

Immunofluorescence analysis of U937 cells using TLR2 pAb at dilution of 1:200 (40x lens).