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Parkin polyclonal antibody

货号: BS91016

价格：￥ 1140

货期：现货（1-2个工作日）

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详细信息检测数据实验指南文献

No. :BS91016

Product Name :Parkin polyclonal antibody

Swiss-Prot :O60260

Host :Rabbit

Reactivity :Human, Mouse, Rat

Applications :WB, IF/ICC, IHC

Application_all :WB,1:500 - 1:1000|IF/ICC,1:50 - 1:100|IHC,1:50 - 1:200

Background :Parkin is a zinc-finger protein that is related to ubiquitin at the amino terminus. The wild type Parkin gene, which maps to human chromosome 6q25.2-27, encodes a 465 amino acid full-length protein that is expressed as multiple isoforms. Mutations in the Parkin gene are responsible for autosomal recessive juvenile Parkinson's disease and commonly involve deletions of exons 3-5. In humans, Parkin is expressed in a subset of cells of the basal ganglia, midbrain, cerebellum and cerebral cortex, and is subject to alternative splicing in different tissues. Parkin expression is also high in the brainstem of mice, with the majority of immunopositive cells being neurons. The Parkin gene has been identified in a diverse group of organisms including mammals, birds, frog and fruit flies, suggesting that analogous functional roles of the Parkin protein may have been highly conserved during the course of evolution.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity :Parkin polyclonal antibody detects endogenous levels of Parkin protein.

BiowMW :~ 52 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :PRKN; E3 ubiquitin-protein ligase parkin; Parkinson juvenile disease protein 2; Parkinson disease protein 2

Immunogen :KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human Parkin.

Conjugate :Unconjugated

Modification :Unmodified

Western blot analysis of Parkin expression in HepG2 (A), SHSY5Y (B), SW480 (C) whole cell lysates.

Immunohistochemical analysis of Parkin staining in human brain formalin fixed paraffin embedded tissue section.

Immunofluorescent analysis of Parkin staining in HepG2 cells.

免疫沉淀（IP）