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IBA1 polyclonal antibody

货号: BS90681

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS90681

Product Name :IBA1 polyclonal antibody

Swiss-Prot :P55008

Host :Rabbit

Reactivity :Human, Mouse, Rat

Applications :WB IHC-P IF/ICC

Application_all :WB 1:1:500-1:1000 ICC/IF 1:50-1:200 IHC-P 1:50-1:100

Background :Ionized calcium-binding adapter molecule 1 (Iba1), also known as allograft inflammatory factor-1 (AIF-1), is a 147 amino acid cytoplasmic, calcium-binding protein that is thought to play a role in macrophage activation and function. Iba1, containing two EF domains, is induced by cytokines and interferons. In an unstimulated state, Iba1 colocalizes with actin, and upon stimulation, translocates to lamellipodia. It is also a marker of human microglia and is expressed by macrophages in injured skeletal muscle. The gene encoding Iba1 maps to chromosome 6p21.33 and resides in the tumor necrosis factor (TNF) cluster of genes located in the region represented by the human major histocompatibility complex (MHC).

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at +4°Cafter thawing. Aliquot store at -20°Cor -80°CAvoid repeated freeze / thaw cycles.

Specificity :IBA1 polyclonal antibody detects endogenous levels of IBA1 protein.

BiowMW :~ 17 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :AIF1; AIF-1; IBA1; IRT-1; IRT1; Iba1

Immunogen :Recombinant fusion protein containing a sequence corresponding to amino acids 1-147 of human AIF1/IBA1 (NP_001614.3).

Conjugate :Unconjugated

Modification :Unmodified

Western blot analysis of extracts of THP-1 cells, using IBA1 antibody at 1:1000 dilution.

Immunofluorescence analysis of rat brain cells using IBA1 pAb at dilution of 1:50 (40x lens).

(+)-Borneol exerts neuroprotective effects via suppressing the NF-κB pathway in the pilocarpine-induced epileptogenesis rat model

JournalBRAIN RESEARCH

ApplicationWB

IF3.61

SpeciesRat

PMID37127175
Expose to high doses of folic acid during pregnancy causes adolescent anxiety- and depression-like behaviors in offspring mice

JournalJOURNAL OF AFFECTIVE DISORDERS

ApplicationWB

IF4.9

Species

PMID39299590
(+)-Borneol inhibits neuroinflammation and M1 phenotype polarization of microglia in epileptogenesis through the TLR4-NFκB signaling pathway

Journal10.3389/fnins.2024.1497102

ApplicationWB

IF3.2

SpeciesMouse

PMID39605791