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CBFA2T2 polyclonal antibody

货号: BS8660

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS8660

Product Name :CBFA2T2 polyclonal antibody

Swiss-Prot :O43439

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IF

Application_all :WB 1:500 - 1:2000 IF 1:50 - 1:100

Background :In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :CBFA2T2 polyclonal antibody detects endogenous levels of CBFA2T2 protein.

BiowMW :~ 67kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Protein CBFA2T2; ETO homologous on chromosome 20; MTG8-like protein; MTG8-related protein 1; Myeloid translocation-related protein 1; p85; CBFA2T2; EHT, MTGR1

Immunogen :Recombinant full length Human CBFA2T2.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of extracts of various cell lines, using CBFA2T2 antibody.

Immunofluorescence analysis of U20S cell using CBFA2T2 antibody.