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C1R polyclonal antibody

货号: BS8518

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS8518

Product Name :C1R polyclonal antibody

Swiss-Prot :P00736

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IF/ICC

Application_all :WB,1:500 - 1:1000|IF/ICC,1:50 - 1:200

Background :The complement component proteins, C1, C3, C4, and C5, are potent anaphylatoxins that are released during complement activation. Binding of these proteins to their respective G protein-coupled receptors induces proinflammatory events, such as cellular degranulation, smooth muscle contraction, arachidonic acid metabolism, cytokine release, leukocyte activation, and cellular chemotaxis. C1q, together with proenzymes C1r and C1s, yield C1, the first component of the classical pathways of the serum complement system. C1 consists of a calcium dependent trimolecular complex of C1r, C1s and C1q in a 2:2:1 ratio. C1r is a dimer formed of two identical chains that are activated by cleavage into two chains, A and B.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :C1R polyclonal antibody detects endogenous levels of C1R protein.

BiowMW :~ 55 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Complement C1r subcomponent; Complement component 1 subcomponent r; Complement C1r subcomponent light chain; C1R

Immunogen :KLH-conjugated synthetic peptide encompassing a sequence within the center region of human Complement C1R.

Conjugate :Unconjugated

Modification :Unmodified

Western blot analysis of Complement C1R expression in Hela (A), A549 (B), mouse liver (C), rat liver (D) whole cell lysates.

Immunofluorescent analysis of Complement C1R staining in C6 cells.

免疫沉淀（IP）

免疫组织化学（IHC）