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Estrogen Receptor beta polyclonal antibody

货号: BS8465

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS8465

Product Name :Estrogen Receptor beta polyclonal antibody

Swiss-Prot :Q92731

Host :Rabbit

Reactivity :Human, Mouse, Rat

Applications :WB

Application_all :WB,1:500 - 1:2000

Background :This gene encodes a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors. The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus, cytoplasm, and mitochondria. Upon binding to 17beta-estradiol or related ligands, the encoded protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription. Some isoforms dominantly inhibit the activity of other estrogen receptor family members. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been fully characterized.

Product :1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Polyclonal Antibodies

BiowMW :59KDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :ESR2;ER-BETA;ESR-BETA;ESRB;ESTRB;Erb;NR3A2

Immunogen :Recombinant fusion protein of human Estrogen Receptor beta(NP_001201832.1).

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of various lysates, using Estrogen Receptor beta antibody at 1:2067 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit .
Exposure time: 20s.

Mechanisms of Gefitinib-mediated reversal of tamoxifen resistance in MCF-7 breast cancer cells by inducing ERα re-expression

JournalScientific Reports

ApplicationWB

IF4.011

SpeciesHuman

PMID25644501
Concomitant high expression of ERα36, EGFR and HER2 is associated with aggressive behaviors of papillary thyroid carcinomas

JournalScientific Reports

ApplicationIHC

IF3.998

SpeciesHuman

PMID28947799
Role of metformin in inhibiting estrogen‑induced proliferation and regulating ERα and ERβ expression in human endometrial cancer cells

JournalOncology Letters

ApplicationWB

IF2.311

SpeciesHuman

PMID29085506