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Cleaved Notch1 polyclonal antibody

货号: BS80388

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS80388

Product Name :Cleaved Notch1 polyclonal antibody

Swiss-Prot :P46531

Host :Rabbit

Reactivity :Human, Mouse, Rat

Applications :WB, IHC, IF/ICC

Application_all :WB,1:500 - 1:1000|IHC,1:100 - 1:200|IF/ICC,1:100 - 1:500

Background :This gene encodes a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple different domain types. Notch signaling is an evolutionarily conserved intercellular signaling pathway that regulates interactions between physically adjacent cells through binding of Notch family receptors to their cognate ligands. The encoded preproprotein is proteolytically processed in the trans-Golgi network to generate two polypeptide chains that heterodimerize to form the mature cell-surface receptor. This receptor plays a role in the development of numerous cell and tissue types. Mutations in this gene are associated with aortic valve disease, Adams-Oliver syndrome, T-cell acute lymphoblastic leukemia, chronic lymphocytic leukemia, and head and neck squamous cell carcinoma.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Cleaved Notch1 polyclonal antibody detects endogenous levels of Cleaved Notch1 protein.

BiowMW :~ 120 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :AOS5;AOVD1;TAN1;hN1;NOTCH1;Activated NOTCH1;notch 1

Immunogen :KLH-conjugated synthetic peptide encompassing a sequence within the center region of human NOTCH1.

Conjugate :Unconjugated

Modification :Cleaved

Western blot analysis of NOTCH1 expression in Myla2059 (A) whole cell lysates.

Immunohistochemical analysis of NOTCH1 staining in human brain formalin fixed paraffin embedded tissue section.

Immunofluorescent analysis of NOTCH1 staining in HeLa cells.

免疫沉淀（IP）