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ATM polyclonal antibody

货号: BS79971

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS79971

Product Name :ATM polyclonal antibody

Swiss-Prot :Q13315

Host :Rabbit

Reactivity :Human, Rat

Applications :IF/ICC

Application_all :IF/ICC,1:50 - 1:200

Background :The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder.

Product :1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Unmodification

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :AT1;ATA;ATC;ATD;ATDC;ATE;TEL1;TELO1;ATM

Immunogen :Recombinant fusion protein of human ATM(NP_000042.3).

Conjugate :Unconjugated

Modification :Unmodification

Immunofluorescence analysis of U2OS cells using ATM antibody at dilution of 1:100. Blue: DAPI for nuclear staining.