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Complement factor B (CFB) polyclonal antibody

货号: BS79797

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS79797

Product Name :Complement factor B (CFB) polyclonal antibody

Swiss-Prot :P00751

Host :Rabbit

Reactivity :Mouse, Rat

Applications :WB

Application_all :WB,1:1000 - 1:2000

Background :This gene encodes complement factor B, a component of the alternative pathway of complement activation. Factor B circulates in the blood as a single chain polypeptide. Upon activation of the alternative pathway, it is cleaved by complement factor D yielding the noncatalytic chain Ba and the catalytic subunit Bb. The active subunit Bb is a serine protease which associates with C3b to form the alternative pathway C3 convertase. Bb is involved in the proliferation of preactivated B lymphocytes, while Ba inhibits their proliferation. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. This cluster includes several genes involved in regulation of the immune reaction. Polymorphisms in this gene are associated with a reduced risk of age-related macular degeneration. The polyadenylation site of this gene is 421 bp from the 5' end of the gene for complement component 2.

Product :1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Unmodification

BiowMW :100kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :CFB;AHUS4;ARMD14;BF;BFD;CFAB;CFBD;FB;FBI12;GBG;H2-Bf;PBF2

Immunogen :Recombinant fusion protein of human factor B (CFB)(NP_001701.2).

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of extracts of rat serum, using Complement factor B antibody at 1:3000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit .
Exposure time: 10s.