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EP300 polyclonal antibody

货号: BS79789

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS79789

Product Name :EP300 polyclonal antibody

Swiss-Prot :Q09472

Host :Rabbit

Reactivity :Human, Mouse, Rat

Applications :IHC, IF/ICC

Application_all :IHC,1:50 - 1:200|IF/ICC,1:50 - 1:200

Background :This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer.

Product :1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Unmodification

BiowMW :Refer to figures

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :EP300;KAT3B;RSTS2;p300

Immunogen :Recombinant fusion protein of human EP300(NP_001420.2).

Conjugate :Unconjugated

Modification :Unmodification

Immunohistochemistry of paraffin-embedded human lung cancer using EP300 antibody at dilution of 1:100 .Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.

Immunofluorescence analysis of U2OS cells using EP300 Rabbit pAb at dilution of 1:100 . Blue: DAPI for nuclear staining.