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Ataxin-1 polyclonal antibody

货号: BS7968

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS7968

Product Name :Ataxin-1 polyclonal antibody

Swiss-Prot :P54253

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IF

Application_all :WB: 1:500~1:2000 IF: 1:50~1:200

Background :Ataxin-1, also designated spinocerebellar ataxia type 1 protein (Sca-1), is differentially expressed and localizes to both the cytoplasm and the nucleus. Mutations in Ataxin-1 are associated with the onset of the autosomal dominant neurodegenerative disorder spinocerebellar ataxia type 1 (SCA-1), which is characterized by progressive neuronal loss in the cerebellum, muscle wasting and ataxia. In Purkinje cells, where SCA-1 is predominantly observed, Ataxin-1 has been shown to directly associate with the Purkinje-enriched leucine-rich acidic nuclear protein (LANP) and the nuclear matrix-associated protein promyelocytic leukemia protein PML. In SCA-1, Ataxin-1 is mutated to encode a polyglutamine protein that forms nuclear aggregates, which interact significantly more strongly with LANP and contribute to the pathogenesis of SCA-1.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Ataxin-1 polyclonal antibody detects endogenous levels of Ataxin-1 protein.

BiowMW :~ 84 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :alternative ataxin1; Ataxin-1; ATX1; ATX1_HUMAN; Atxn1; D6S504E; SCA1; Spinocerebellar ataxia type 1 protein;

Immunogen :Recombinant full length Human Ataxin-1.

Conjugate :Unconjugated

Modification :Unmodification

WesternBlot (WB) analysis of Ataxin-1 polyclonal antibody

免疫沉淀（IP）

免疫组织化学（IHC）

免疫荧光（IF）