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Phospho-STING/TMEM173-S366 polyclonal antibody

货号: BS79500

价格：￥ 1680

货期：现货（1-2个工作日）

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No. :BS79500

Product Name :Phospho-STING/TMEM173-S366 polyclonal antibody

Swiss-Prot :Q86WV6

Host :Rabbit

Reactivity :Human, Mouse, Rat

Applications :WB

Application_all :WB,1:500 - 1:1000

Background :This gene encodes a five transmembrane protein that functions as a major regulator of the innate immune response to viral and bacterial infections. The encoded protein is a pattern recognition receptor that detects cytosolic nucleic acids and transmits signals that activate type I interferon responses. The encoded protein has also been shown to play a role in apoptotic signaling by associating with type II major histocompatibility complex. Mutations in this gene are the cause of infantile-onset STING-associated vasculopathy. Alternate splicing results in multiple transcript variants.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Phospho-STING/TMEM173-S366 polyclonal antibody detects endogenous levels of STING/TMEM173 protein only when phosphorylated at S366.

BiowMW :33KDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :TMEM173;ERIS;MITA;MPYS;NET23;SAVI;STING;hMITA;hSTING

Immunogen :A synthetic phosphorylated peptide around S366 of human STING/TMEM173(NP_938023.1).

Conjugate :Unconjugated

Modification :Phosphorylated

Western blot analysis of Phospho-STING/TMEM173-S366 expression in Hela-UV treated (A), mouse lung (B), mouse muscle (C), rat muscle (D) whole cell lysates.

Thiamet-G ameliorates Parkinson's disease-associated cognitive impairment via increasing O-GlcNAcylation of STING in the microglia

JournalNEUROCHEMISTRY INTERNATIONAL

ApplicationWB

IF4

SpeciesMouse

PMID40578440