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Phospho-Histone H2A-S129 polyclonal antibody

货号: BS79470

价格：￥ 1680

货期：现货（1-2个工作日）

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No. :BS79470

Product Name :Phospho-Histone H2A-S129 polyclonal antibody

Swiss-Prot :P04911

Host :Rabbit

Reactivity :Human, Rat

Applications :IHC

Application_all :IHC,1:50 - 1:200

Background :Core component of nucleosome which plays a central role in DNA double strand break (DSB) repair. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Product :1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Phosphorylated

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :H2A1;SPT11

Immunogen :A synthetic phosphorylated peptide around S129 of saccharomyces cerevisiae Histone H2A(NP_010511.3?).

Conjugate :Unconjugated

Modification :Phosphorylated

Immunohistochemistry of paraffin-embedded rat liver using Phospho-Histone H2A-S129 antibody at dilution of 1:100 .Perform microwave antigen retrieval with 10 mM Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.

Immunohistochemistry of paraffin-embedded human breast cancer using Phospho-Histone H2A-S129 antibody at dilution of 1:100 .Perform microwave antigen retrieval with 10 mM Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.