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Phospho-PLN-S16/T17 polyclonal antibody

货号: BS79464
价格 1680
货期 现货(1-2个工作日)
25ul 50ul 100ul 200ul
No. :BS79464
Product Name :Phospho-PLN-S16/T17 polyclonal antibody
Swiss-Prot :P26678
Host :Rabbit
Reactivity :Human, Mouse, Rat
Applications :WB
Application_all :WB,1:500 - 1:2000
Background :The protein encoded by this gene is found as a pentamer and is a major substrate for the cAMP-dependent protein kinase in cardiac muscle. The encoded protein is an inhibitor of cardiac muscle sarcoplasmic reticulum Ca(2+)-ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation of the protein. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. The encoded protein is a key regulator of cardiac diastolic function. Mutations in this gene are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure, and also familial hypertrophic cardiomyopathy.
Product :1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :Phosphorylated
BiowMW :13kDa/17KDa
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :CMD1P;CMH18;PLB;PLN
Immunogen :A synthetic phosphorylated peptide around S16 & T17 of human PLN(NP_002658.1).
Conjugate :Unconjugated
Modification :Phosphorylated
Western blot analysis of extracts of various cell lines, using Phospho-PLN-S16/T17 antibody at 1:1000 dilution.Hela cells and C6 cells were treated by CIP at 37℃ for 1 hour.
Secondary antibody: HRP Goat Anti-Rabbit IgG at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit .
Exposure time: 10s.

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400-660-9091

电话:025-68037686

地址:江苏生命科技创新园F6幢1层

订购:nanjing03@biogot.com

服务:biorase01@biogot.com

合作:lvyun@biogot.com

支持:may@biogot.com