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Phospho-CD115/CSF-1R-Y708 polyclonal antibody

货号: BS79418
价格 1680
货期 现货(1-2个工作日)
25ul 50ul 100ul 200ul
No. :BS79418
Product Name :Phospho-CD115/CSF-1R-Y708 polyclonal antibody
Swiss-Prot :P07333
Host :Rabbit
Reactivity :Human
Applications :WB
Application_all :WB,1:500 - 1:2000
Background :The protein encoded by this gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. The encoded protein is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in this gene have been associated with a predisposition to myeloid malignancy. The first intron of this gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction. Alternative splicing results in multiple transcript variants. Expression of a splice variant from an LTR promoter has been found in Hodgkin lymphoma (HL), HL cell lines and anaplastic large cell lymphoma.
Product :1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :Phosphorylated
BiowMW :175KDa
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :CSF1R;C-FMS;CD115;CSF-1R;CSFR;FIM2;FMS;HDLS;M-CSF-R;BANDDOS
Immunogen :A synthetic phosphorylated peptide around Y708 of human CSF1R(NP_005202.2).
Conjugate :Unconjugated
Modification :Phosphorylated
Western blot analysis of extracts of K-562 cells, using Phospho-CD115/CSF-1R-Y708 antibody at 1:1000 dilution.K-562 cells were treated by G-CSF at 37℃ for 30 minutes after serum-starvation overnight.
Secondary antibody: HRP Goat Anti-Rabbit IgG at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit .
Exposure time: 1s.

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400-660-9091

电话:025-68037686

地址:江苏生命科技创新园F6幢1层

订购:nanjing03@biogot.com

服务:biorase01@biogot.com

合作:lvyun@biogot.com

支持:may@biogot.com