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Phospho-Tyk2-Y1054/1055 polyclonal antibody

货号: BS79399

价格：￥ 1680

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS79399

Product Name :Phospho-Tyk2-Y1054/1055 polyclonal antibody

Swiss-Prot :P29597

Host :Rabbit

Reactivity :Mouse

Applications :WB

Application_all :WB,1:500 - 1:1000

Background :This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E.

Product :1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Phosphorylated

BiowMW :134KDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :TYK2;IMD35;JTK1

Immunogen :A synthetic phosphorylated peptide around Y1054 & Y1055 of human Tyk2(NP_003322.3).

Conjugate :Unconjugated

Modification :Phosphorylated

Western blot analysis of extracts of NIH/3T3 cells, using Phospho-Tyk2-Y1054/1055 Rabbit pAb at 1:1000 dilution.NIH/3T3 cells were treated by IFN-α at 37℃ for 30 minutes after serum-starvation overnight.
Secondary antibody: HRP Goat Anti-Rabbit IgG at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% BSA.
Detection: ECL Enhanced Kit .
Exposure time: 180s.