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Phospho-mTOR-S2481 polyclonal antibody

货号: BS79380

价格：￥ 1680

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS79380

Product Name :Phospho-mTOR-S2481 polyclonal antibody

Swiss-Prot :P42345

Host :Rabbit

Reactivity :Human, Mouse

Applications :WB

Application_all :WB,1:500 - 1:2000

Background :The protein encoded by this gene belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. The ANGPTL7 gene is located in an intron of this gene.

Product :1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Phosphorylated

BiowMW :289kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :FRAP;FRAP1;FRAP2;RAFT1;RAPT1;SKS;mTOR;MTOR

Immunogen :A synthetic phosphorylated peptide around S2481 of human mTOR(NP_004949.1).

Conjugate :Unconjugated

Modification :Phosphorylated

Western blot analysis of extracts of C2C12 cells, using Phospho-mTOR-S2481 antibody at 1:1000 dilution.C2C12 cells were treated by 10% FBS at 37℃ for 30 minutes after serum-starvation overnight.
Secondary antibody: HRP Goat Anti-Rabbit IgG at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% BSA.
Detection: ECL Enhanced Kit .
Exposure time: 5min.

Capsaicin reverses cisplatin resistance in tongue squamous cell carcinoma by inhibiting the Warburg effect and facilitating mitochondrial-dependent apoptosis via the AMPK/AKT/mTOR axis

JournalCELL BIOLOGY INTERNATIONAL

ApplicationWB

IF3.9

SpeciesHuman

PMID38706122
Capsaicin combined with cisplatin inhibits TGF-β1-induced EMT and TSCC cells migration via the Claudin-1/PI3K/AKT/mTOR signaling pathway

JournalCancer Cell International

ApplicationWB

IF5.3

SpeciesHuman

PMID39198820