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BAG5 polyclonal antibody

货号: BS7862

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS7862

Product Name :BAG5 polyclonal antibody

Swiss-Prot :Q9UL15

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC

Application_all :WB: 1:500~1:2000 IHC: 1:50~1:200

Background :Bag-5 (Bcl-2-associated athanogene 5), also known as Bag family molecular chaperone regulator 5, is a member of the Bag family of proteins and contains four Bag domains. Via their Bag domain, Bag proteins bind with high affinity to the HSC 70/HSP 70 ATPase domain, regulating chaperone activity and apoptosis. Bag-5 is a component of the HSP 70/Parkin complex and acts to inhibit Parkin E3 ubiquitin ligase activity and HSP 70 chaperone activity. In this complex, Bag-5 directly interacts with the ATPase domain of HSP 70 and the N-terminal linker region of Parkin. Bag-5 expression is induced upon dopaminergic neuron injury and functions to sensitize the neurons to injuryinduced cell death. In addition, Bag-5 may be a useful target in therapies for neurodegenerative diseases such as Parkinson’s disease which is caused by a mutation in the gene encoding Parkin.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :BAG5 polyclonal antibody detects endogenous levels of BAG5 protein.

BiowMW :~ 51 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :BAG family molecular chaperone regulator 5; BAG-5; BAG5; BAG5_HUMAN; Bcl-2-associated athanogene 5; BCL2 associated athanogene 5; KIAA0873;

Immunogen :Recombinant full length Human BAG5.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of extracts of various cell lines, using BAG5 antibody.

Immunohistochemistry of paraffin-embedded human stomach using BAG5 antibody.

Immunohistochemistry of paraffin-embedded rat brain using BAG5 antibody.