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Phospho-CFL1-Y139 polyclonal antibody

货号: BS74141

价格：￥ 1680

货期：现货（1-2个工作日）

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No. :BS74141

Product Name :Phospho-CFL1-Y139 polyclonal antibody

Swiss-Prot :P23528

Host :Rabbit

Reactivity :Human, Mouse, Rat

Applications :IHC

Application_all :IHC,1:50 - 1:100

Background :The protein encoded by this gene can polymerize and depolymerize F-actin and G-actin in a pH-dependent manner. Increased phosphorylation of this protein by LIM kinase aids in Rho-induced reorganization of the actin cytoskeleton. Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. It is involved in the translocation of actin-cofilin complex from cytoplasm to nucleus.[supplied by OMIM, Apr 2004]

Product :1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Phosphorylated

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :CFL1;CFL;HEL-S-15;cofilin;cofilin-1

Immunogen :A synthetic phosphorylated peptide around Y139 of human Phospho-CFL1-Y139(NP_005498.1).

Conjugate :Unconjugated

Modification :Phosphorylated

Immunohistochemistry of paraffin-embedded human colon carcinoma using Phospho-CFL1-Y139 Rabbit pAb at dilution of 1:50 .Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6.0 before commencing with IHC staining protocol.

Immunohistochemistry of paraffin-embedded mouse kidney using Phospho-CFL1-Y139 Rabbit pAb at dilution of 1:50 .Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6.0 before commencing with IHC staining protocol.

Immunohistochemistry of paraffin-embedded rat kidney using Phospho-CFL1-Y139 Rabbit pAb at dilution of 1:50 .Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6.0 before commencing with IHC staining protocol.