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GPR109A/HM74A/HCAR2 polyclonal antibody

货号: BS72723

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS72723

Product Name :GPR109A/HM74A/HCAR2 polyclonal antibody

Swiss-Prot :Q8TDS4

Host :Rabbit

Reactivity :Human, Mouse, Rat

Applications :WB, IHC, IF/ICC

Application_all :WB,1:500 - 1:1000|IHC,1:50 - 1:100|IF/ICC,1:50 - 1:200

Background :Acts as a high affinity receptor for both nicotinic acid (also known as niacin and (D-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i-protein-mediated inhibition of adenylyl cyclase. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Mediates nicotinic acid-induced apoptosis in mature neutrophils. Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and phosphorylation of target proteins, leading to neutrophil apoptosis. The rank order of potency for the displacement of nicotinic acid binding is 5-methyl pyrazole-3-carboxylic acid = pyridine-3-acetic acid > acifran > 5-methyl nicotinic acid = acipimox >> nicotinuric acid = nicotinamide.

Product :1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :GPR109A/HM74A/HCAR2 polyclonal antibody detects endogenous levels of GPR109A/HM74A/HCAR2 protein.

BiowMW :~ 41 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :HCAR2; GPR109A; HCA2; HM74A; NIACR1; Hydroxycarboxylic acid receptor 2; G-protein coupled receptor 109A; G-protein coupled receptor HM74A; Niacin receptor 1; Nicotinic acid receptor

Immunogen :KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human GPR109A/HM74A/HCAR2.

Conjugate :Unconjugated

Modification :Unmodified

Western blot analysis of GPR109A/HM74A/HCAR2 expression in Myla2059 (A), MCF7 (B), mouse spleen (C), rat spleen (D) whole cell lysates.

Immunohistochemical analysis of GPR109A/HM74A/HCAR2 staining in human kidney cancer formalin fixed paraffin embedded tissue section.

Immunofluorescent analysis of GPR109A/HM74A/HCAR2 staining in MCF7 cells.

Short‑chain fatty acid butyrate: A novel shield against chronic gastric ulcer

JournalExperimental and Therapeutic Medicine

ApplicationIHC

IF1.785

SpeciesMouse

PMID33732302