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RYR2 polyclonal antibody

货号: BS72313

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS72313

Product Name :RYR2 polyclonal antibody

Swiss-Prot :Q92736

Host :Rabbit

Reactivity :Human, Mouse, Rat

Applications :WB, IF/ICC

Application_all :WB,1:500 - 1:2000|IF/ICC,1:50 - 1:200

Background :This gene encodes a ryanodine receptor found in cardiac muscle sarcoplasmic reticulum. The encoded protein is one of the components of a calcium channel, composed of a tetramer of the ryanodine receptor proteins and a tetramer of FK506 binding protein 1B proteins, that supplies calcium to cardiac muscle. Mutations in this gene are associated with stress-induced polymorphic ventricular tachycardia and arrhythmogenic right ventricular dysplasia.

Product :1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Polyclonal Antibodies

BiowMW :564KDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :RYR2;ARVC2;ARVD2;RYR-2;RyR;VTSIP;RYR2

Immunogen :A synthetic peptide of human RYR2(NP_001026.2).

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of extracts of Mouse heart, using RYR2 antibody at 1:710 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit .
Exposure time: 30s.

Immunofluorescence analysis of mouse heart cells using RYR2 Rabbit pAb at dilution of 1:200 . Blue: DAPI for nuclear staining.

Hypertrophy of lymphoid organs is a possible phenotypic characteristic of R420W mutation of the cardiac ryanodine receptor gene: A study using a knock-in mouse model

JournalLegal Medicine

ApplicationIHC

IF1.376

SpeciesMouse

PMID