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LGR5/GPR49 polyclonal antibody

货号: BS72291

价格：￥ 1140

货期：现货（1-2个工作日）

25ul 50ul 100ul 200ul

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说明书 MSDS SHIP

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No. :BS72291

Product Name :LGR5/GPR49 polyclonal antibody

Swiss-Prot :O75473

Host :Rabbit

Reactivity :Human, Mouse, Rat

Applications :WB, IP

Application_all :WB,1:500 - 1:2000|IP,1:50 - 1:200

Background :The protein encoded by this gene is a leucine-rich repeat-containing receptor (LGR) and member of the G protein-coupled, 7-transmembrane receptor (GPCR) superfamily. The encoded protein is a receptor for R-spondins and is involved in the canonical Wnt signaling pathway. This protein plays a role in the formation and maintenance of adult intestinal stem cells during postembryonic development. Several transcript variants encoding different isoforms have been found for this gene.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :LGR5/GPR49 polyclonal antibody detects endogenous levels of LGR5/GPR49 protein.

BiowMW :100KDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :LGR5;FEX;GPR49;GPR67;GRP49;HG38

Immunogen :Recombinant fusion protein of human LGR5/GPR49(NP_003658.1).

Conjugate :Unconjugated

Modification :Unmodified

Western blot analysis of LGR5/GPR49 expression in A431 (A), mouse brain (B), rat skeletal muscle (C) whole cell lysates.

TET2-BCLAF1 transcription repression complex epigenetically regulates the expression of colorectal cancer gene Ascl2 via methylation of its promoter

JournalJOURNAL OF BIOLOGICAL CHEMISTRY

ApplicationWB

IF5.486

SpeciesHuman

PMID35660018