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PLAU polyclonal antibody

货号: BS6927

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS6927

Product Name :PLAU polyclonal antibody

Swiss-Prot :P00749

Host :Rabbit

Reactivity :Human, Mouse, Rat

Applications :WB

Application_all :WB,1:500 - 1:2000

Background :This gene encodes a secreted serine protease that converts plasminogen to plasmin. The encoded preproprotein is proteolytically processed to generate A and B polypeptide chains. These chains associate via a single disulfide bond to form the catalytically inactive high molecular weight urokinase-type plasminogen activator (HMW-uPA). HMW-uPA can be further processed into the catalytically active low molecular weight urokinase-type plasminogen activator (LMW-uPA). This low molecular weight form does not bind to the urokinase-type plasminogen activator receptor. Mutations in this gene may be associated with Quebec platelet disorder and late-onset Alzheimer's disease. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.

Product :1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Polyclonal Antibodies

BiowMW :49kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :PLAU;ATF;BDPLT5;QPD;UPA;URK;u-PA;urokinase

Immunogen :Recombinant fusion protein of human PLAU(NP_002649.1).

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of extracts of various cell lines, using PLAU antibody at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit .
Exposure time: 30s.

Effects of ulinastatin and docetaxel on breast cancer invasion and expression of uPA, uPAR and ERK

JournalJournal Of Experimental & Clinical Cancer Research

ApplicationWB,IHC

IF11.161

SpeciesMouse,Human

PMID21798065
A mechanism for abnormal angiogenesis in human radiation proctitis: analysis of expression profile for angiogenic factors

JournalJournal Of Gastroenterology

ApplicationIHC

IF7.527

SpeciesHuman

PMID
GPER in CAFs regulates hypoxia-driven breast cancer invasion in a CTGF-dependent manner

JournalOncology Reports

ApplicationWB

IF3.906

SpeciesHuman

PMID25647524
Stromal-derived factor-1α/CXCL12-CXCR4 chemotactic pathway promotes perineural invasion in pancreatic cancer

JournalOncotarget

ApplicationWB

IF0

SpeciesHuman

PMID25605248