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ALOX5 polyclonal antibody

货号: BS6913

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS6913

Product Name :ALOX5 polyclonal antibody

Swiss-Prot :P09917

Host :Rabbit

Reactivity :Human, Mouse, Rat

Applications :WB, IHC, IF/ICC

Application_all :WB,1:500 - 1:2000|IHC,1:50 - 1:200|IF/ICC,1:50 - 1:200

Background :This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :ALOX5 polyclonal antibody detects endogenous levels of ALOX5 protein.

BiowMW :~ 78 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :ALOX5;5-LO;5-LOX;5LPG;LOG5

Immunogen :Recombinant fusion protein of human 5-Lipoxygenase.

Conjugate :Unconjugated

Modification :Unmodified

Western blot analysis of 5-Lipoxygenase expression in A549 (A) whole cell lysates.

Immunohistochemical analysis of 5-Lipoxygenase staining in rat brain formalin fixed paraffin embedded tissue section.

Immunofluorescent analysis of 5-Lipoxygenase staining in C6 cells.

免疫沉淀（IP）