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CDKN1C/p57 Kip2 polyclonal antibody

货号: BS6876

价格：￥ 1140

货期：现货（1-2个工作日）

25ul 50ul 100ul 200ul

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS6876

Product Name :CDKN1C/p57 Kip2 polyclonal antibody

Swiss-Prot :P49918

Host :Rabbit

Reactivity :Human, Mouse, Rat

Applications :WB

Application_all :WB,1:500 - 1:2000

Background :This gene is imprinted, with preferential expression of the maternal allele. The encoded protein is a tight-binding, strong inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith-Wiedemann syndorome, suggesting that this gene is a tumor suppressor candidate. Three transcript variants encoding two different isoforms have been found for this gene.

Product :1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Polyclonal Antibodies

BiowMW :57KDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :CDKN1C;BWCR;BWS;KIP2;WBS;p57;p57Kip2

Immunogen :Recombinant fusion protein of human CDKN1C/p57 Kip2(NP_000067.1).

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of extracts of various cell lines, using CDKN1C/p57 Kip2 antibody at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit .
Exposure time: 180s.

mTORC1 regulates PTHrP to coordinate chondrocyte growth, proliferation and differentiation

JournalNature Communications

ApplicationWB, IHC, IF

IF11.878

SpeciesMouse

PMID27039827
The differential susceptibilities of MCF-7 and MDA-MB-231 cells to the cytotoxic effects of curcumin are associated with the PI3K/Akt-SKP2-Cip/Kips pathway

JournalCancer Cell International

ApplicationWB

IF4.175

SpeciesHuman

PMID25530715
Overexpression of transcription factor FoxA2 in the developing skeleton causes an enlargement of the cartilage hypertrophic zone, but it does not trigger ectopic differentiation in immature chondrocytes

JournalBONE

ApplicationIHC

IF4.398

SpeciesMouse

PMID35398294