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COL18A1 polyclonal antibody

货号: BS6856

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS6856

Product Name :COL18A1 polyclonal antibody

Swiss-Prot :P39060

Host :Rabbit

Reactivity :Mouse

Applications :WB

Application_all :WB,1:500 - 1:1000

Background :This gene encodes the alpha chain of type XVIII collagen. This collagen is one of the multiplexins, extracellular matrix proteins that contain multiple triple-helix domains (collagenous domains) interrupted by non-collagenous domains. A long isoform of the protein has an N-terminal domain that is homologous to the extracellular part of frizzled receptors. Proteolytic processing at several endogenous cleavage sites in the C-terminal domain results in production of endostatin, a potent antiangiogenic protein that is able to inhibit angiogenesis and tumor growth. Mutations in this gene are associated with Knobloch syndrome. The main features of this syndrome involve retinal abnormalities, so type XVIII collagen may play an important role in retinal structure and in neural tube closure. Alternative splicing results in multiple transcript variants.

Product :1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Polyclonal Antibodies

BiowMW :240kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :COL18A1;KNO;KNO1;KS

Immunogen :A synthetic peptide of human COL18A1(NP_085059.2).

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of extracts of mouse lung, using COL18A1 antibody at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Enhanced Kit .
Exposure time: 90s.