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PD-L1/CD274 polyclonal antibody

货号: BS6850

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS6850

Product Name :PD-L1/CD274 polyclonal antibody

Swiss-Prot :Q9NZQ7

Host :Rabbit

Reactivity :Human, Mouse, Rat

Applications :WB, IHC

Application_all :WB,1:500 - 1:1000|IHC,1:50 - 1:100

Background :This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma. Alternative splicing results in multiple transcript variants.

Product :1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :PD-L1/CD274 polyclonal antibody detects endogenous levels of PD-L1/CD274 protein.

BiowMW :35KDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :B7-H;B7H1;PDL1;PD-L1;PDCD1L1;PDCD1LG1;CD274

Immunogen :KLH-conjugated synthetic peptide encompassing a sequence within the center region of human PD-L1/CD274.

Conjugate :Unconjugated

Modification :Unmodified

Western blot analysis of PD-L1/CD274 expression in mouse lung (A) whole cell lysates.

Immunohistochemical analysis of PD-L1/CD274 staining in human lung cancer formalin fixed paraffin embedded tissue section.

Attenuated Salmonella carrying siRNA-PD-L1 and radiation combinatorial therapy induces tumor regression on HCC through T cell-mediated immuno-enhancement

JournalCell Death Discovery

ApplicationWB，IF

IF7

SpeciesMouse

PMID37640735
Comparative study of [18F]AlF-PAI-PDL1p and [68Ga]Ga-PAI-PDL1p as novel PD-L1 targeting PET probes for tumor imaging

JournalBIOORGANIC CHEMISTRY

ApplicationIHC,IF

IF4.5

SpeciesMouse,Hamster

PMID39079391