中国 EN 400-660-9091

联系我们

电话:025-68037686

地址:江苏生命科技创新园F6幢1层

订购:nanjing03@biogot.com

服务:biorase01@biogot.com

合作:lvyun@biogot.com

支持:may@biogot.com

PD-L1/CD274 polyclonal antibody

货号: BS6850
价格 1140
货期 现货(1-2个工作日)
25ul 50ul 100ul 200ul
No. :BS6850
Product Name :PD-L1/CD274 polyclonal antibody
Swiss-Prot :Q9NZQ7
Host :Rabbit
Reactivity :Human, Mouse, Rat
Applications :WB, IHC
Application_all :WB,1:500 - 1:1000|IHC,1:50 - 1:100
Background :This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma. Alternative splicing results in multiple transcript variants.
Product :1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :PD-L1/CD274 polyclonal antibody detects endogenous levels of PD-L1/CD274 protein.
BiowMW :35KDa
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :B7-H;B7H1;PDL1;PD-L1;PDCD1L1;PDCD1LG1;CD274
Immunogen :KLH-conjugated synthetic peptide encompassing a sequence within the center region of human PD-L1/CD274.
Conjugate :Unconjugated
Modification :Unmodified
Western blot analysis of PD-L1/CD274 expression in mouse lung (A) whole cell lysates.
Immunohistochemical analysis of PD-L1/CD274 staining in human lung cancer formalin fixed paraffin embedded tissue section.
  • Attenuated Salmonella carrying siRNA-PD-L1 and radiation combinatorial therapy induces tumor regression on HCC through T cell-mediated immuno-enhancement
    JournalCell Death Discovery
    ApplicationWB,IF
    IF7
    SpeciesMouse
  • Comparative study of [18F]AlF-PAI-PDL1p and [68Ga]Ga-PAI-PDL1p as novel PD-L1 targeting PET probes for tumor imaging
    JournalBIOORGANIC CHEMISTRY
    ApplicationIHC,IF
    IF4.5
    SpeciesMouse,Hamster

关注我们

400-660-9091

电话:025-68037686

地址:江苏生命科技创新园F6幢1层

订购:nanjing03@biogot.com

服务:biorase01@biogot.com

合作:lvyun@biogot.com

支持:may@biogot.com