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DDIT3/CHOP polyclonal antibody

货号: BS6814

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS6814

Product Name :DDIT3/CHOP polyclonal antibody

Swiss-Prot :P35638

Host :Rabbit

Reactivity :Human, Mouse, Rat

Applications :WB, IHC, IF/ICC

Application_all :WB,1:500 - 1:2000|IF/ICC,1:50 - 1:200|IHC,1:50 - 1:200

Background :This gene encodes a member of the CCAAT/enhancer-binding protein (C/EBP) family of transcription factors. The protein functions as a dominant-negative inhibitor by forming heterodimers with other C/EBP members, such as C/EBP and LAP (liver activator protein), and preventing their DNA binding activity. The protein is implicated in adipogenesis and erythropoiesis, is activated by endoplasmic reticulum stress, and promotes apoptosis. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in myxoid liposarcomas or Ewing sarcoma. Multiple alternatively spliced transcript variants encoding two isoforms with different length have been identified.

Product :1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Polyclonal Antibodies

BiowMW :27KDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :DDIT3;CEBPZ;CHOP;CHOP-10;CHOP10;GADD153;C/EBPzeta;DDIT3 / CHOP

Immunogen :Recombinant fusion protein of human DDIT3/CHOP(NP_004074.2).

Conjugate :Unconjugated

Modification :Unmodification

Immunohistochemistry of paraffin-embedded human prostate cancer using DDIT3/CHOP Rabbit pAb at dilution of 1:200 .Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6.0 before commencing with IHC staining protocol.

Immunohistochemistry of paraffin-embedded mouse kidney using DDIT3/CHOP Rabbit pAb at dilution of 1:200 .Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6.0 before commencing with IHC staining protocol.

Immunohistochemistry of paraffin-embedded rat kidney using DDIT3/CHOP Rabbit pAb at dilution of 1:200 .Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6.0 before commencing with IHC staining protocol.

Restraint stress aggravates rat kidney injury caused by a crush injury through endoplasmic reticulum stress

JournalJournal of Trauma and Acute Care Surgery

ApplicationWB

IF3.313

SpeciesRat

PMID
Hydrogen sulfide protects H9c2 cells against doxorubicin-induced cardiotoxicity through inhibition of endoplasmic reticulum stress

JournalMolecular And Cellular Biochemistry

ApplicationWB

IF2.884

SpeciesRat

PMID22203419
n-3 Polyunsaturated fatty acids protect against pancreatic β-cell damage due to ER stress and prevent diabetes development

JournalMolecular Nutrition & Food Research

ApplicationWB

IF5.914

SpeciesMouse,Rat

PMID26080997
Chronic restraint stress promotes learning and memory impairment due to enhanced neuronal endoplasmic reticulum stress in the frontal cortex and hippocampus in male mice

JournalInternational Journal Of Molecular Medicine

ApplicationIHC

IF2.928

SpeciesMouse

PMID25482165
Magnesium isoglycyrrhizinate attenuates acute alcohol-induced hepatic steatosis in a zebrafish model by regulating lipid metabolism and ER stress

JournalNutrition & Metabolism

ApplicationWB

IF4.169

SpeciesZebrafsh

PMID35331265