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KEAP1 polyclonal antibody

货号: BS6783

价格：￥ 1140

货期：现货（1-2个工作日）

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详细信息检测数据实验指南文献

No. :BS6783

Product Name :KEAP1 polyclonal antibody

Swiss-Prot :Q14145

Host :Rabbit

Reactivity :Human, Mouse, Rat

Applications :WB, IHC, IF/ICC

Application_all :WB,1:500 - 1:1000|IHC,1:50 - 1:200|IF/ICC,1:50 - 1:200

Background :This gene encodes a protein containing KELCH-1 like domains, as well as a BTB/POZ domain. Kelch-like ECH-associated protein 1 interacts with NF-E2-related factor 2 in a redox-sensitive manner and the dissociation of the proteins in the cytoplasm is followed by transportation of NF-E2-related factor 2 to the nucleus. This interaction results in the expression of the catalytic subunit of gamma-glutamylcysteine synthetase. Two alternatively spliced transcript variants encoding the same isoform have been found for this gene.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :KEAP1 Polyclonal Antibody detects endogenous levels of KEAP1 protein.

BiowMW :~ 60 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :KEAP1;INrf2;KLHL19

Immunogen :Recombinant fusion protein of human KEAP1(NP_036421.2).

Conjugate :Unconjugated

Modification :Unmodified

Western blot analysis of KEAP1 expression in mouse brain (A), rat brain (B) whole cell lysates.

Immunohistochemical analysis of KEAP1 staining in rat kidney formalin fixed paraffin embedded tissue section.

Immunofluorescent analysis of KEAP1 staining in U2OS cells.

Activation of Liver X Receptor Improves Viability of Adipose-Derived Mesenchymal Stem Cells to Attenuate Myocardial Ischemia Injury Through TLR4/NF-κB and Keap-1/Nrf-2 Signaling Pathways

JournalAntioxidants & Redox Signaling

ApplicationWB

IF6.323

SpeciesMouse

PMID24915051
Anti-neuroinflammatory effect of Sophoraflavanone G from Sophora alopecuroides in LPS-activated BV2 microglia by MAPK, JAK/STAT and Nrf2/HO-1 signaling pathways

JournalPhytomedicine

ApplicationWB

IF5.34

SpeciesMouse

PMID27823627
Orientin alleviates cognitive deficits and oxidative stress in Aβ1–42-induced mouse model of Alzheimer's disease

JournalLife Sciences

ApplicationWB

IF3.647

SpeciesMouse

PMID25497709
Dihydromyricetin modulates p62 and autophagy crosstalk with the Keap-1/Nrf2 pathway to alleviate ethanol-induced hepatic injury

JournalToxicology Letters

ApplicationWB,IHC

IF3.569

SpeciesMouse

PMID28419832
Probiotic Pediococcus pentosaceus ameliorates MPTP-induced oxidative stress via regulating the gut microbiota–gut–brain axis

JournalFrontiers in Cellular and Infection Microbiology

ApplicationWB

IF6.073

SpeciesMouse

PMID36439235