Product Name :GLP-1R polyclonal antibody
Reactivity :Human, Mouse, Rat
Applications :WB IHC IF/ICC
Application_all :WB: 1:500~1:1000
IHC: 1:100~1:200
IF/ICC: 1:100~1:500
Background :This gene encodes a 7-transmembrane protein that functions as a receptor for glucagon-like peptide 1 (GLP-1) hormone, which stimulates glucose-induced insulin secretion. This receptor, which functions at the cell surface, becomes internalized in response to GLP-1 and GLP-1 analogs, and it plays an important role in the signaling cascades leading to insulin secretion. It also displays neuroprotective effects in animal models. Polymorphisms in this gene are associated with diabetes. The protein is an important drug target for the treatment of type 2 diabetes and stroke. Alternative splicing of this gene results in multiple transcript variants.
Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :GLP-1R polyclonal antibody detects endogenous levels of GLP-1R protein.
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :GLP1R;GLP-1;GLP-1-R;GLP-1R
Immunogen :KLH-conjugated synthetic peptide encompassing a sequence within the center region of human GLP-1R.
