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NLRP3 polyclonal antibody

货号: BS66103

价格：￥ 1140

货期：现货（1-2个工作日）

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详细信息检测数据实验指南文献

No. :BS66103

Product Name :NLRP3 polyclonal antibody

Swiss-Prot :Q96P20

Host :Rabbit

Reactivity :Human, Mouse, Rat

Applications :WB, IHC, ICC/IF

Application_all :WB (1/500 - 1/1000), IHC (1/50 - 1/200)

Background :This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PY- CARD/ASC, which contains a caspase recruitment do- main, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activa- tor of NF-kappaB signaling, and it plays a role in the reg- ulation of inflammation, the immune response, and apop- tosis. Mutations in this gene are associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutane- ous and articular (CINCA) syndrome, and neonatal-onset multisystem inflammatory disease (NOMID). Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5' UTR structures are suggested by available data; however, insufficient evidence is available to determine if all of the represented 5' UTR splice patterns are biologically valid.

Product :1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Polyclonal Antibodies

BiowMW :~ 118 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :NLRP3; AGTAVPRL; AII; AVP; C1orf7; CIAS1; CLR1.1; FCAS; FCAS1; FCU; MWS; NALP3; PYPAF1

Immunogen :Recombinant protein of human NLRP3.

Western blot analysis of NLRP3 expression in HT29 (A), mouse brain (B), rat brain (C) whole cell lysates.

Immunohistochemical analysis of NLRP3 staining in mouse spleen formalin fixed paraffin embedded tissue section.

Immunofluorescent analysis of NLRP3 staining in Raw264.7 cells.

Therapeutic potential of atorvastatin in ischemic stroke: an investigation into its anti-inflammatory effect by targeting the gut-brain axis

JournalJournal of Translational Medicine

ApplicationWB

IF7.5

SpeciesMouse

PMID40629397
Genistein maintains intestinal homeostasis in colitis mice via activating GPR30-Nrf2 signaling pathway

JournalJOURNAL OF NUTRITIONAL BIOCHEMISTRY

ApplicationWB

IF4.9

SpeciesPorcine,Mouse

PMID40684867
A Novel Function of Glycerol Kinase Alleviates LPS-Induced Inflammatory Responses by the p38/STAT3 Pathway and Mitigates ROS Generation in Kupffer Cells

JournalAntioxidants

ApplicationWB,IF

IF6.6

Species

PMID
Jujuboside A Alleviates Facial Allodynia of CCI-ION Rats by Inhibiting the Expression of P2X7 Receptor in the Spinal Trigeminal Subnucleus Caudalis

JournalJOURNAL OF ORAL PATHOLOGY & MEDICINE

ApplicationWB

IF2.3

SpeciesRat

PMID41213795