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phospho-CaMK2 alpha (Thr305) Polyclonal Antibody

货号: BS65911

价格：￥ 1350

货期：现货（1-2个工作日）

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No. :BS65911

Product Name :phospho-CaMK2 alpha (Thr305) Polyclonal Antibody

Swiss-Prot :Q13554

Host :Rabbit

Reactivity :Human, Mouse, Rat

Applications :WB, IHC

Application_all :WB,1:500 - 1:1000|IHC,1:50 - 1:100

Background :Ca2+/CalmodulinDependent Protein Kinase II (CaM Kinase II) is a multifunctional calcium and calmodulindependent protein kinase that mediates cellular responses to a wide variety of intercellular signals. CaM Kinase II has been shown to regulate diverse cellular functions including synaptic plasticity, neurotransmitter synthesis and release, gene expression, ion channel function, carbohydrate metabolism, cytoskeletal function, and Ca2+homeostasis. Phosphorylation of Thr286 on the kinase produces an autonomously active form of CaM Kinase II. Autophosphorylation of Thr305 inhibits the activity CaM Kinase II. Phosphorylation at this site appears to reduce the association of CaM Kinase II with the PSD and reduce LTP and learning.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :phospho-CaMK2 alpha (Thr305) Polyclonal Antibody detects endogenous levels of CaMK2 alpha protein only when phosphorylated at Thr305.

BiowMW :50 kD

Note :For research use only, not for use in diagnostic procedure.

Pathway :Phospholipase Signaling,Contribution of Soluble Factors to EMT,G Protein-coupled Receptors Signaling to MAPK Erk,ErbB HER Signaling,

Alternative Name :CAMK2A; CAMKA; KIAA0968; Calcium/calmodulin-dependent protein kinase type II subunit alpha; CaM kinase II subunit alpha; CaMK-II subunit alpha; CAMK2B; CAM2; CAMK2; CAMKB; Calcium/calmodulin-dependent protein kinase type II subunit beta; CaM kinase II sub

Immunogen :KLH-conjugated synthetic phosphopeptide corresponding to residues surrounding T305 of human CaMK2 alpha protein.

Conjugate :Unconjugated

Modification :Phosphorylated

Western blot analysis of phospho-CaMK2 alpha (Thr305) expression in HEK293T (A), U87MG (B), A549 (C), rat brain (D) whole cell lysates.

Immunohistochemical analysis of phospho-CaMK2 alpha (Thr305) staining in human brain formalin fixed paraffin embedded tissue section.